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ASCO quiz Part-1

1. A 42-year-old premenopausal lady was diagnosed with carcinoma breast, Gr. II IDC, cT3N1M0, ER+ PR+ HER2-ve, Ki67 50%. After 8 cycles of NACT, she underwent BCS and chest wall RT. The final stage was ypT2N0M0. She was found to have germline BRCA-1 mutation-positive. What would you recommend? *This question is required.
2. Mr. X, a 65-year-old gentleman had c/o haematuria. The evaluation revealed a right Renal Cell Carcinoma, clear cell histology and a single metastatic pulmonary lesion in the right lower lobe. He underwent radical nephrectomy and pulmonary metastasectomy. How will you treat him further? *This question is required.
3. Mr. Z, a 70-year-old fit gentleman, was diagnosed with metastatic prostate cancer (Gleason 9) with bone mets a year ago and had undergone bilateral orchidectomy and was on bicalutamide and monthly zoledronic acid. He had a progressive increase in PSA levels and a PSMA scan showed new metastases in bilateral lungs and an increase in size and number of bone lesions. What would be the preferred line of management? *This question is required.
4. Mrs. G, a 50-year-old lady with TNBC was treated with surgery and adjuvant chemotherapy presented with bilateral lung and multiple liver metastases within 10 months of completion of adjuvant therapy. She was given 1st line single-agent docetaxel 12 months back. She has now presented with progressive disease with new liver lesions. What would be your treatment option of choice for 2nd line therapy? *This question is required.
5. A 60-year-old gentleman who presented with dysphagia was diagnosed with locally advanced carcinoma of the lower 1/3rd of the oesophagus. He underwent Neoadjuvant chemoradiation for the same and then interval resection. Histopathology was reported as Grade II adenocarcinoma, ypT2NxM0. What will you offer as adjuvant therapy? *This question is required.
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